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Patients receiving snris and metoclopramide should be monitored for the emergence of serotonin syndrome, neuroleptic malignant syndrome-like reactions, or other adverse effects.
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These usually are seen during the first 24-48 hours of treatment with metoclopramide, occur more frequently in pediatric patients and adult patients less than 30 years of age and are even more frequent at the higher doses used in prophylaxis of vomiting due to cancer chemotherapy.
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a few cases of neutropenia, leukopenia, or agranulocytosis, generally without clearcut relationship to metoclopramide.