Information about Imuran.
Azathioprine suppresses disease manifestations as well as underlying pathology in animal models of autoimmune diseaseFor examplethe severity of adjuvant arthritis is reduced by azathioprine.
IMURAN is teratogenic in rabbits and mice when given in doses equivalent to the human dose5 mg/kg dailyAbnormalities included skeletal malformations and visceral anomalies11.
A small clinical study has indicated that standard therapeutic doses of Imuran do not deleteriously affect the response to polyvalent pneumococcal vaccineas assessed on the basis of mean anti-capsular specific antibody concentration.
As there is in vitro evidence that aminosalicyclate but lexapro without a script. derivatives(egolsalazinemesalazine or sulphasalazineinhibit the TPMT enzymethey should be administered with caution to patients receiving concurrent Imuran therapysee 4.4 Special Warning and Special Precautions for Use
In patients with renal and/or hepatic insufficiencydosages should be given at the lower end of the normal rangesee Special Warnings and Precautions for Use for further details
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