A prospective study involving 63 patients evaluated the risk of ocular toxicity due to tamoxifen 20 mg daily for a mean duration of 25 months range 6 to 51 months .
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in a reanalysis of this trial, 77 patients with cisplatin-refractory disease had an orr of 13 with tamoxifen.
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prognostic value of oncotype-based rs was seen both in patients treated with tamoxifen and confirmed for patients treated with arimidex.
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there is an increased risk of thromboembolic events occurring when cytotoxic agents are used in combination with tamoxifen.
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43 genotyping therefore has the potential for identification of women who have these cyp2d6 phenotypes and for whom the use of tamoxifen is associated with poor outcomes.
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